Clinical Trials & Research
Last Updated 2/23/2010 12:18:00 PM
The Heart & Vascular Institute conducts advanced clinical research comparable to academic medical centers. Our physicians are making a variety of clinical trials available to their patients, giving them access to new experimental therapies for conditions that may not respond adequately to existing approaches, as well as advancing the treatment technologies for the region.
Carotid Artery Disease
| Clinical trial |
Purpose |
| ACT I |
To evaluate the equivalence of carotid artery stenting using the Abbott Vascular Xact(R) stent and Emboshield(R) embolic protection system when compared to endarterectomy in low-surgical-risk patients. This is a multicenter randomized study with three out of four patients receiving a stent. |
| EMBOLDEN |
A non-randomized study evaluating the 30 day safety and effectiveness of the GORE Embolic Filter used with FDA approved carotid stents in comparison to previous carotid stent studies utilizing distal embolic protection. |
| Post-market studies |
To evaluate the use of FDA-approved carotid stents and embolic protection systems in high-risk patients: CHOICE (Abbott), SAPPHIRE WW (Cordis), and CREATE PAS (ev3) |
Cardiovascular Trials
| Clinical trial |
Purpose |
| Schering-Plough IMPROVE-IT |
A study to establish the clinical benefit and safety of VYTORIN(R) (ezetimibe/simvastatin) versus simvastatin alone in high-risk patients presenting with acute coronary syndrome. |
| Accumetrics Gravitas |
A study to determine if patients treated with an adjusted dose of the drug Plavix(R) have fewer occurrences of major cardiac events after a drug-eluting stent. |
Lower Extremity Disease
| Clinical trial |
Purpose |
| iCAST |
A non-randomized study to evaluate the non-inferiority of the iCAST covered stent (Atrium Medical) for treating iliac artery stenosis in patients with de novo or restenotic lesions in the common and/or external iliac arteries. |
| DURABILITY |
A non-randomized study to evaluate the use of the PROTEGE(R) EverFlex(TM) Nitinol stent system (ev3) in lesions of the SFA/Proximal Pop. |