El Camino Heart & Vascular Institute Clinical Trials

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Heart & Vascular Institute Clinical Trials

Last Updated 3/23/2010 9:14:01 AM

The Heart & Vascular Institute conducts advanced clinical research comparable to academic medical centers. Our physicians are making a variety of clinical trials available to their patients, giving them access to new experimental therapies for conditions that may not respond adequately to existing approaches, as well as advancing the treatment technologies for the region.

Carotid Artery Disease

Clinical trial	Purpose
ACT I	To evaluate the equivalence of carotid artery stenting using the Abbott Vascular Xact^(R) stent and Emboshield^(R) embolic protection system when compared to endarterectomy in low-surgical-risk patients. This is a multicenter randomized study with three out of four patients receiving a stent.
EMBOLDEN	A non-randomized study evaluating the 30 day safety and effectiveness of the GORE Embolic Filter used with FDA approved carotid stents in comparison to previous carotid stent studies utilizing distal embolic protection.
Post-market studies	To evaluate the use of FDA-approved carotid stents and embolic protection systems in high-risk patients: CHOICE (Abbott), SAPPHIRE WW (Cordis), and CREATE PAS (ev3)

Cardiovascular Trials

Clinical trial	Purpose
Schering-Plough IMPROVE-IT	A study to establish the clinical benefit and safety of VYTORIN^(R) (ezetimibe/simvastatin) versus simvastatin alone in high-risk patients presenting with acute coronary syndrome.

Lower Extremity Disease

Clinical trial	Purpose
iCAST	A non-randomized study to evaluate the non-inferiority of the iCAST covered stent (Atrium Medical) for treating iliac artery stenosis in patients with de novo or restenotic lesions in the common and/or external iliac arteries.
DURABILITY	A non-randomized study to evaluate the use of the PROTEGE^(R) EverFlex^(TM) Nitinol stent system (ev3) in lesions of the SFA/Proximal Pop.

Mitral Valve Regurgitation

Clinical trial	Purpose
EVEREST II (REALISM)	Continued access registry to provide additional information regarding the endovascular approach to treatment of mitral valve regurgitation using the Evalve Cardiovascular Valve Repair System (MitraClip) and to evaluate changes in functional capacity after successful MitraClip treatment.

Video: Mitral Valve Regurgitation, its Complications, and Treatments

Chad Rammohan, MD, discusses mitral valve regurgitation, including traditional forms of treatment such as open-heart surgery, and a newer treatment called the Evalve procedure. The Evalve procedure uses an investigational device that is pending FDA approval; the procedure is available in an FDA-approved clinical trial at El Camino Hospital.